The Asia-Pacific Economic Cooperation (APEC) has been promoting digital transformation as a key mean for regional economic growth and economic integration. The digitalization agenda within APEC is further accelerating since the COVID-19 pandemic. Recently at the APEC Leaders’ Meeting in November 2020, the APEC Putrajaya Vision 2040 was adopted, which includes “Innovation and Digitalization” addressing inclusive economic participation through digital economy and technology as a focus area for the next 20 years. However, it is still difficult to expect visible outcomes in the field of digital inclusion within APEC. Upon this backdrop, this article examines the progress of digitalization in the Asia-Pacific region, compares and analyzes the digital transformation policies of major economies in the region, demonstrates the effect of the digital gap on economic performance in the region, and goes on to produce policy implications.